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![TCF7L2 Antibody (N-term) [APR10388G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/864425/1156492/logo__92149.1659788186__73750.1659860166.png?c=2 "TCF7L2 Antibody (N-term) [APR10388G]"){kind=logo}
![TCF7L2 Antibody (N-term) [APR10388G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/864425/1156492/logo__92149.1659788186__73750.1659860166.png?c=2 "TCF7L2 Antibody (N-term) [APR10388G]"){kind=logo}
Product Description
TCF7L2 Antibody (N-term) [APR10388G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This TCF7L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human TCF7L2.
Cellular Localisation: Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies
Molecular Weight: 67919
Clone: Polyclonal
Gene Name: TCF7L2
Gene ID: 6934
Function: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Summary: Tissue Location: Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, TCF7L2, TCF4
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