Euro
USD
British Pound
NULL
![TSC1 Antibody (Center T417) [APR10572G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/869043/1161110/logo__92149.1659788186__38065.1659865323.png?c=2 "TSC1 Antibody (Center T417) [APR10572G]"){kind=logo}
![TSC1 Antibody (Center T417) [APR10572G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/869043/1161110/logo__92149.1659788186__38065.1659865323.png?c=2 "TSC1 Antibody (Center T417) [APR10572G]"){kind=logo}
Product Description
TSC1 Antibody (Center T417) [APR10572G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the Central region of human TSC1.
Cellular Localisation: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Molecular Weight: 129767
Clone: Polyclonal
Gene Name: TSC1
Gene ID: 7248
Function: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400) . Seems not to be required for TSC2 GAP activity towards RHEB (PubMed:15340059) . Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity) . Acts as a co- chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed:29127155) . Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed:29127155) . Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155) . Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed:16464865, PubMed:29127155) .
Summary: Tissue Location: Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
![TSC1 Antibody (Center T417) [APR10572G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/869043/1161110/logo__92149.1659788186__38065.1659865323.png?c=2 "TSC1 Antibody (Center T417) [APR10572G]"){kind=logo}
![Phospho-rat TSC1 (T417) Antibody [APR32078G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/872323/1164390/logo__92149.1659788186__97086.1659868425.png?c=2 "Phospho-rat TSC1 (T417) Antibody [APR32078G]"){kind=logo}
