Product Description
UNC13B Antibody (Center) [AMM05462G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.
Cellular Localisation: Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Cell junction, synapse. Note=Localized to synapses Translocated to the plasma membrane in response to phorbol ester binding (By similarity) .
Molecular Weight: 180679
Clone: Polyclonal
Gene Name: UNC13B (HGNC:12566)
Gene ID: 10497
Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity) . Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) . In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity) .
Summary: Tissue Location: Expressed in kidney cortical epithelial cells and brain.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC
Dilution: WB--1:1000 FC--1:10~50
Synonyms: Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13