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Product Description
UPK1A Antibody (C-term) [AMM08701G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This UPK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-217 amino acids from the C-terminal region of human UPK1A.
Cellular Localisation: Membrane; Multi-pass membrane protein.
Molecular Weight: 28879
Clone: Polyclonal
Gene Name: UPK1A
Gene ID: 11045
Function: Component of the asymmetric unit membrane (AUM) ; a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity) .
Summary: Tissue Location: High expression restricted to ureteric urothelium (most superficial cells) ; low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Uroplakin-1a, UP1a, Tetraspanin-21, Tspan-21, Uroplakin Ia, UPIa, UPKa, UPK1A, TSPAN21
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