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Product Description
PDL1 Detection Set | SD8500 | ProSci
Host: llama
Reactivity: Human
Homology: N/A
Immunogen: PD-L1 antibodies were raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
Tested Application: E, Flow, ICC, IF
Application: N/A
Specificity: N/A
Purification: PD-L1 Antibodies are affinity chromatography purified via Nickel column.Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
Clonality: Monoclonal
Isotype: sdab
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS containing 0.02% sodium azide.
Concentration: Antibody 1 mg/mL
Storage Condition: PD-L1 antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Background: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.
User Note: Optimal dilutions for each application to be determined by the researcher. Antibodies have a C-terminal HIS 6-Tag followed by a myc-Tag for detection and have been tested using ProSci's PM-7669 (cMyc-tag Antibody [5G5H7]).
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