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Product Description
BSCL2 Antibody | 15-615 | ProSci
Host: Rabbit
Reactivity: Mouse, Rat
Homology: N/A
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human BSCL2 (NP_116056.3) .
Research Area: Neuroscience, Obesity
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: Mouse brain
Positive Control 2: Mouse lung
Positive Control 3: Mouse testis
Positive Control 4: Rat brain
Positive Control 5: Rat testis
Positive Control 6: N/A
Molecular Weight: Observed: 46kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: GNG3LG, HMN5, PELD, SPG17, seipin, BSCL2, seipin lipid droplet biogenesis associated, Berardinelli-Seip congenital lipodystrophy 2 (seipin) , Bernardinelli-Seip congenital lipodystrophy type 2 protein
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2) .
