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Product Description
PLAU Antibody | 18-556 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PLAU (NP_002649.1) .
Research Area: Cancer, Neuroscience, Signal Transduction
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: HT-1080
Positive Control 2: Mouse kidney
Positive Control 3: Mouse brain
Positive Control 4: Rat kidney
Positive Control 5: Rat brain
Positive Control 6: N/A
Molecular Weight: Observed: 49kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: PLAU, plasminogen activator, urokinase, HGNC:9052, ATF, UPA, URK, u-PA, U-plasminogen activator, antagonist of uPA, urinary, urokinase plasminogen activator, urokinase-type plasminogen activator amino-terminal fragment, urokinase-t, QPD, BDPLT5
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA) . HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA) . This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
