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![IL-2 Antibody [1Q8G7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/572583/805717/porsci_lo__79508.1648973713__18796.1649090927.png?c=2 "IL-2 Antibody [1Q8G7]")
![IL-2 Antibody [1Q8G7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/572583/805717/porsci_lo__79508.1648973713__18796.1649090927.png?c=2 "IL-2 Antibody [1Q8G7]")
Product Description
IL-2 Antibody [1Q8G7] | 11-090 | ProSci
Host: Rabbit
Reactivity: Virus
Homology: N/A
Immunogen: Recombinant Human IL2 Protein, amino acids Ala21-Thr153
Research Area: Infectious Disease, COVID-19
Tested Application: E
Application: Human IL-2 Sanwich ELISA Immunoassay:
ELISA Capture: Recommended Concentration: 2-8ug/mL, Sample: Human IL-2 Monoclonal Antibody, Rabbit MAb（CAP)
ELISA Detection: Recommended Concentration: 0.15-0.5ug/mL, Sample: Human IL-2 Monoclonal Antibody, Rabbit MAb (DET)
Standard: Recommended Concentration: 0.78-50pg/mL, Sample: Recombinant Human IL2 Protein
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.
Clonality: Recombinant Monoclonal
Clone: 1Q8G7
Isotype: Rabbit IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied as a 0.2um filtered solution in PBS, pH 7.4.
Concentration: 1mg/ml
Storage Condition: This antibody can be stored at 2˚C to -8˚C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚C to -80˚C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Alternate Name: IL-2; TCGF; lymphokine
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Interleukin-2 (IL-2) is a O-glycosylated, four alpha -helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. IL-2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL-2 and IL-2 R alpha synthesis. IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells.
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