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![SARS-COV-2 Spike RBD Protein Antibody [1J9I8] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/572169/804759/porsci_lo__79508.1648973713__57918.1649090843.png?c=2 "SARS-COV-2 Spike RBD Protein Antibody [1J9I8] (Biotin)")
![SARS-COV-2 Spike RBD Protein Antibody [1J9I8] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/572169/804759/porsci_lo__79508.1648973713__57918.1649090843.png?c=2 "SARS-COV-2 Spike RBD Protein Antibody [1J9I8] (Biotin)")
Product Description
SARS-COV-2 Spike RBD Protein Antibody [1J9I8] (Biotin) | 11-103 | ProSci
Host: Rabbit
Reactivity: Virus
Homology: N/A
Immunogen: HEK293 derived SARS-COV-2 SPIKE RBD, amino acids Arg319-Phe541
Research Area: Infectious Disease, COVID-19, Antibody Pairs
Tested Application: E
Application: SARS-CoV-2 Spike RBD Sanwich ELISA Immunoassay:
ELISA Capture: Recommended Concentration: 1-4ug/mL, Sample: SARS-COV-2 Spike RBD Protein Antibody (CAP)
ELISA Detection: Recommended Concentration: 0.03-0.15ug/mL, Sample: Biotinylated SARS-COV-2 Spike RBD Protein Antibody (DET)
Standard: Recommended Concentration: 15.6-1000pg/mL, Sample: Recombinant SARS-COV-2 Spike RBD Protein with His tag
Specificiy: SARS-CoV-2
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.
Clonality: Recombinant Monoclonal
Clone: 1J9I8
Isotype: Rabbit IgG
Conjugate: Biotin
Physical State: Liquid
Buffer: Supplied as a 0.2um filtered solution in PBS, pH 7.4.
Concentration: 1mg/ml
Storage Condition: This antibody can be stored at 2˚C to -8˚C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚C to -80˚C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Alternate Name: spike glycoprotein
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It''s been reported that SARS-CoV-2 (COVID-19 coronavirus, 2019-nCoV) can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. S1 mainly contains a receptor binding domain (RBD) , which is responsible for recognizing the cell surface receptor. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD) , leading to a higher mortality rate.
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