Product Description
DHCR24 Antibody | 19-642 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1) .
Research Area: Apoptosis, Cancer, Cell Cycle, Neuroscience
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: U-87MG
Positive Control 2: HT-29
Positive Control 3: PC-12
Positive Control 4: NCI-H460
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 55kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: Delta (24) -sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a flavin adenine dinucleotide (FAD) -dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.