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Product Description
EIF4G2 Antibody | 18-858 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 750-850 of human EIF4G2 (NP_001409.3) .
Research Area: Apoptosis, Cell Cycle
Tested Application: WB, IHC
Application: WB: 1:500 - 1:1000
IHC: 1:100 - 1:200
Specificiy: N/A
Positive Control 1: SW480
Positive Control 2: A-549
Positive Control 3: BT-474
Positive Control 4: 293T
Positive Control 5: SH-SY5Y
Positive Control 6: Mouse kidney
Molecular Weight: Observed: 102kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: EIF4G2, AAG1, DAP5, FLJ41344, NAT1, p97, P97
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F) , which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
