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Product Description
KHDC1 Antibody | 7423 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: KHDC1 antibody was raised against a 15 amino acid peptide near the amino terminus of human KHDC1.
The immunogen is located within amino acids 30 - 80 of KHDC1.
Research Area: Apoptosis
Tested Application: E, WB, IHC-P
Application: KHDC1 antibody can be used for detection of KHDC1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificiy: KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist; this antibody will only detect the longest isoform.
Positive Control 1: Cat. No. 1464 - Rat Liver Tissue Lysate
Positive Control 2: Cat. No. 10-201 - Human Liver Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 18 kDa
Observed: 26 kDa
Validation: N/A
Isoform: N/A
Purification: KHDC1 Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: KHDC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: KHDC1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: KHDC1 Antibody: NDG1, C6orf148, bA257K9.4, KH homology domain-containing protein 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: KHDC1 Antibody: KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1) . KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1) , a key translational regulator controlling the polyA length of mRNAs (2, 3) . KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3, 4) .
