Product Description
SRC Antibody | 13-143 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 410-536 of human SRC (NP_005408.1) .
Research Area: Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction
Tested Application: WB, IP
Application: WB: 1:500 - 1:1000
IP: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: HT-29
Positive Control 2: DU145
Positive Control 3: A-549
Positive Control 4: Mouse brain
Positive Control 5: Mouse lung
Positive Control 6: Rat testis
Molecular Weight: Observed: 60kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: SRC, ASV, Pp60c-src, Tyrosine kinase pp60c-src, Tyrosine-protein kinase SRC-1, v-src, C-SRC, p60-Src, Proto-oncogene c-Src, SRC1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.