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Product Description
TOP1MT Antibody | 16-110 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 470-550 of human TOP1MT (NP_443195.1) .
Research Area: Cancer
Tested Application: WB
Application: WB: 1:200 - 1:2000
Specificiy: N/A
Positive Control 1: A-549
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 70kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: DNA topoisomerase I, mitochondrial, mitochondrial topoisomerase IB, topoisomerase (DNA) I, mitochondrial
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
![TOP1MT Antibody [TOP1MT/488]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/575188/811586/porsci_lo__79508.1648973713__26506.1649091852.png?c=2 "TOP1MT Antibody [TOP1MT/488]")
