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Product Description
HSD11B2 Antibody | XW-8141 | ProSci
Host: Chicken
Reactivity: Human, Rat, Chicken
Homology: N/A
Immunogen: 181-405
Research Area: Other
Tested Application: WB
Application: Corticosteroid 11-β-dehydrogenase, isozyme 2 antibody can be used for the detection of Corticosteroid 11-β-dehydrogenase, isozyme 2 by Western Blot.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 44.1 kDa (calculated)
Validation: N/A
Isoform: N/A
Purification: Immunoaffinity Purified
Clonality: Polyclonal
Clone: N/A
Isotype: N/A
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Phosphate-Buffered Saline. No preservatives added.
Concentration: 1 mg/mL
Storage Condition: HSD11B2 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: HSD11K, Corticosteroid 11-beta-dehydrogenase isozyme 2, 11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, AME, AME1, HSD2, HSD11K, SDR9C3, Corticosteroid 11bdehydrogenase, isozyme 2, 11-beta-HSD2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: FUNCTION: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
DISEASE: Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
