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Product Description
Mycophenolic acid | 10-030 | ProSci
BNR: Chemical
Predicted Molecular Weight: 320, 3
Physical State: Lyophilized
Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Alternate Name: MPA; NSC 129185; Ly 68618; Mycophenolate
Background: Antibiotic [1]. Shows antiviral, antifungal and antitumor properties [1, 2]. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis [3-6, 13]. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation [7, 8]. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform [11]. Inhibits RNA and DNA synthesis [13]. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor [8, 10]. Apoptosis and necrosis inducer [9, 12]. Novel type of inhibitor against RNA guanylyltransferases [14]. Inhibits TNF-α-stimulated MAPK/NF-κB and ROS generation [15]. Autophagy suppressor. Broad-spectrum antiviral compound with inhibitory activity against different coronavirus, including SARS-CoV, MERS-CoV and SARS-CoV-2, cause of COVID-19. It binds to the active site of SARS-CoV-2 papain-like protease (PLpro) possibly inhibiting viral replication.
Disclaimer: This product is for research use only.
Purity: greater than or equal to 98% (HPLC, TLC)
Formula: C17H20O6
Source: Isolated from Penicillium brevi-compactum.
Solubility: Soluble in DMSO (25mg/ml) or water (25mg/ml) .
InChi Key: HPNSFSBZBAHARI-RUDMXATFSA-N
Smiles: COC1=C (C) C2=C (C (=O) OC2) C (O) =C1C\C=C (/C) CCC (O) =O
RTECS: MP8050000
Identity: N/A
Merck Index: 4, 977083333
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