Euro
USD
British Pound
NULL
Product Description
Ritonavir | 10-040 | ProSci
BNR: Chemical
Predicted Molecular Weight: 720, 9
Physical State: Lyophilized
Storage Condition: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Alternate Name: RTV; A-84538; ABT-538; Abbot 84538; NSC 693184
Background: HIV-1 and HIV-2 protease inhibitor. Glucose transporter 1 (GLUT1) and 4 (GLUT4) inhibitor. Inhibits transport of glucose across the plasma membranes of mammalian cells and consequently decreases glycolysis. Useful agent for immunometabolism research. Antitumor agent. Apoptosis inducer and cell proliferation inhibitor in GLUT1/GLUT4 overexpressed cancer cell lines. Tumor cells rely on elevated glucose consumption and metabolism for survival and proliferation. Glucose transporters mediating glucose entry are key proximal rate-limiting checkpoints. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose transporters. The proteinase inhibitor Kaletra, which is a mixture of the HIV-1 proteinase inhibitors lopinavir and ritonavir has been shown to be effective against SARS-CoV and MERS-CoV. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the coronavirus endopeptidase C30 (CEP_C30) of SARS-CoV-2. An initial randomized trial study was not successful.
Disclaimer: This product is for research use only.
Purity: greater than or equal to 98% (HPLC)
Formula: C37H48N6O5S2
Source: N/A
Solubility: Soluble in DMSO (20mg/ml) or DMF (20mg/ml) .
InChi Key: NCDNCNXCDXHOMX-XGKFQTDJSA-N
Smiles: CC (C1=NC (CN (C (N[C@H] (C (N[C@H] (C[C@@H] ([C@@H] (NC (OCC2=CN=CS2) =O) CC3=CC=CC=C3) O) CC4=CC=CC=C4) =O) C (C) C) =O) C) =CS1) C
RTECS: XA5310000
Identity: N/A
Merck Index: N/A
![Recombinant Rat SCF Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671959/929802/logo__42078.1651665136__26163.1651684433.jpg?c=2 "Recombinant Rat SCF Protein [E. coli]"){kind=logo}
