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![CD152 Antibody [9H10]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576622/814500/porsci_lo__79508.1648973713__77292.1649092234.png?c=2 "CD152 Antibody [9H10]")
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Product Description
CD152 Antibody [9H10] | 98-911 | ProSci
Host: Hamster
Reactivity: Mouse
Homology: N/A
Immunogen: Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein
Research Area: Immunology
Tested Application: IHC-Fr, ICC, Flow, Separation
Application: CD152 Antibody [9H10] for use in flow cytometry, ELISA, blocking, and costimulation assays.
Specificiy: CD152
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [9H10]
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: CTLA-4, cytotoxic T-lymphocyte protein 4
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.
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