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![CD279 Antibody [J43.1]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/556173/765192/porsci_lo__79508.1648973713__24229.1649086732.png?c=2 "CD279 Antibody [J43.1]")
![CD279 Antibody [J43.1]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/556173/765192/porsci_lo__79508.1648973713__24229.1649086732.png?c=2 "CD279 Antibody [J43.1]")
Product Description
CD279 Antibody [J43.1] | 76-976 | ProSci
Host: Hamster
Reactivity: Mouse
Homology: N/A
Immunogen: N/A
Research Area: Immunology, Apoptosis, Functional Assays
Tested Application: Flow, IHC, IP
Application: N/A
Specificiy: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1) , a 50-55 kDa glycoprotein of the Ig superfamily.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality: Monoclonal
Clone: J43.1
Isotype: Armenian Hamster IgG
Conjugate: Unconjugated
Physical State: liquid
Buffer: Phosphate-buffered aqueous solution, ph7.2.
Concentration: batch dependent
Storage Condition: The product should be stored undiluted at 4˚C . Do not freeze.
Alternate Name: PD-1, Pdc1, Ly101, Pdcd1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1) , a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.
![CD279 Antibody [J43.1]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/556173/765192/porsci_lo__79508.1648973713__24229.1649086732.png?c=2 "CD279 Antibody [J43.1]")
![CD279 Antibody [J43.1]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/556172/765191/porsci_lo__79508.1648973713__80573.1649086732.png?c=2 "CD279 Antibody [J43.1]")
![CD279 Antibody [J43.1] (PE)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/556175/765194/porsci_lo__79508.1648973713__79709.1649086732.png?c=2 "CD279 Antibody [J43.1] (PE)")
![CD279 Antibody [J43.1] (PE)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/556174/765193/porsci_lo__79508.1648973713__19345.1649086732.png?c=2 "CD279 Antibody [J43.1] (PE)")
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