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![Ly-49C/F/H/I Antibody [14B11] (PE)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576174/813816/porsci_lo__79508.1648973713__66738.1649092143.png?c=2 "Ly-49C/F/H/I Antibody [14B11] (PE)")
![Ly-49C/F/H/I Antibody [14B11] (PE)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/576174/813816/porsci_lo__79508.1648973713__66738.1649092143.png?c=2 "Ly-49C/F/H/I Antibody [14B11] (PE)")
Product Description
Ly-49C/F/H/I Antibody [14B11] (PE) | 98-937 | ProSci
Host: Hamster
Reactivity: Mouse
Homology: N/A
Immunogen: IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice
Research Area: Immunology
Tested Application: IHC-P, IHC-Fr, Flow
Application: Ly-49C/F/H/I Antibody [14B11] for use in flow cytometry assays.
Specificiy: Ly-49C/F/H/I
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [14B11]
Isotype: IgG
Conjugate: PE
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Ly-49
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J) .
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