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Product Description
MKRN3 Antibody | 8145 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: MKRN3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MKRN3.
The immunogen is located within amino acids 400 - 450 of MKRN3.
Research Area: Homeostasis
Tested Application: E, WB, IF
Application: MKRN3 antibody can be used for detection of MKRN3 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: MKRN3 antibody is human specific. MKRN3 antibody is predicted to not cross-react with other members of the MKRN protein family.
Positive Control 1: Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 55 kDa
Observed: 55 kDa
Validation: N/A
Isoform: N/A
Purification: MKRN3 antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: MKRN3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: MKRN3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: Makorin ring finger 3, CPPB2, D15S9, RNF63, ZFP127, ZNF127
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The Makorin ring finger 3 (MKRN3) protein contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. The MKRN3 gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome (1) , but a deletion of the gene does not (2) . A deficiency of MKRN3 has been shown to cause central precocious puberty in humans (3) .
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