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Product Description
MLIP Antibody | 6719 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: MLIP antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human MLIP.
The immunogen is located within the last 50 amino acids of MLIP.
Research Area: Homeostasis
Tested Application: E, WB, IHC-P, IF
Application: MLIP antibody can be used for detection of MLIP by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: At least three isoforms of MLIP are known to exist.
Positive Control 1: Cat. No. 1210 - HEK293 Cell Lysate
Positive Control 2: Cat. No. 10-501 - Human Heart Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: MLIP Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: MLIP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: MLIP antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: MLIP Antibody: C6orf142, C6orf142, Muscular LMNA-interacting protein, Muscular-enriched A-type laminin-interacting protein
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: MLIP Antibody: The muscle-enriched A-type lamin-interacting protein (MLIP) is ubiquitously expressed, although most predominantly in heart, skeletal and smooth muscle, and interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. Decreasing lamin A/C expression with siRNA results in the upregulation and mislocalization of MLIP, suggesting that MLIP localization to the nuclear envelope is dependent on the lamin proteins. It has been suggested that MLIP may function as a tethering protein linking LMNA to factors within the nuclear envelope of within PML bodies
