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Product Description
PACS2 Antibody | 8189 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: PACS2 antibody was raised against a 17 amino acid peptide near the center of human PACS2.
The immunogen is located within amino acids 330 - 380 of PACS2.
Research Area: Homeostasis
Tested Application: E, WB, IHC-P, IF
Application: PACS2 antibody can be used for detection of PACS2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificiy: PACS2 antibody is human, mouse and rat reactive. At least three isoforms of PACS2 are known to exist; this antibody will detect all three. PACS2 antibody is predicted to not cross-react with PACS1.
Positive Control 1: Cat. No. 1403 - Mouse Brain Tissue Lysate
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 98 kDa
Observed: 95 kDa
Validation: N/A
Isoform: N/A
Purification: PACS2 antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PACS2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: PACS2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS1L
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: PACS2 (phosphofurin acidic cluster sorting protein-2) , PACS1L, is an 889 amino acid protein that localizes to both the mitochondrion and the lumen of the endoplasmic reticulum (ER) and belongs to the PACS family (1, 2) . It is expressed in a broad range of tissues with highest expression in skeletal muscle, brain, heart, testis and pancreas (2, ) . PACS2 interacts with Polycystin-2 and BID and functions as a sorting protein that regulates mitochondria-ER communication and is thought to be involved in ion channel trafficking, specifically direct cluster-containing ion channels to distinct subcellular compartments (3-5) .
