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Product Description
SLC29A3 Antibody | 8129 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Immunogen: SLC29A3 antibody was raised against a 19 amino acid peptide near the amino terminus of human SLC29A3.
The immunogen is located within the first 50 amino acids of SLC29A3.
Research Area: Cancer, Homeostasis
Tested Application: E, WB, IHC-P, IF
Application: SLC29A3 antibody can be used for detection of SLC29A3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificiy: SLC29A3 antibody is human, mouse and rat reactive. At least two isoforms of SLC29A3 are known to exist; this antibody will detect both isoforms. SLC29A3 antibody is predicted to not cross-react with other SLC29 proteins.
Positive Control 1: Cat. No. 1410 - Mouse Bladder Tissue Lysate
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 52 kDa
Observed: 51 kDa
Validation: N/A
Isoform: N/A
Purification: SLC29A3 antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: SLC29A3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: SLC29A3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: Solute carrier family 29 member 3, Equilibrative nucleoside transporter 3, ENT3, HCLAP, HJCD, PHID
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: SLC29A3 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1, 2) . SLC29A3 is a transmembrane glycoprotein that localizes to the lysosomal membrane and is a broad selectivity, low affinity nucleoside transporter (3) . Mutations in the SLC29A3 gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism (4) . A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus) , has also been associated with mutations at this locus (5) .
