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Product Description
CDNF Antibody | 4345 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: CDNF antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human CDNF.
The immunogen is located within the first 50 amino acids of CDNF.
Research Area: Neuroscience
Tested Application: E, WB, IHC-P, IF
Application: CDNF antibody can be used for detection of CDNF by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: This antibody does not cross-react with MANF.
Positive Control 1: Cat. No. 1288 - A20 Cell Lysate
Positive Control 2: Cat. No. 10-301 - Human Brain Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: CDNF Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: CDNF Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: CDNF antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: CDNF Antibody: ARMETL1, ARMETL1, Cerebral dopamine neurotrophic factor, ARMET-like protein 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CDNF Antibody: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF) , CDNF can prevent the 6-hydroxylamine (6-OHDA) -induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.
