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Product Description
MALT1 Antibody | 8097 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.
The immunogen is located within amino acids 630 - 680 of MALT1.
Research Area: Cancer, Immunology
Tested Application: E, WB, IHC-P, IF
Application: MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.
Positive Control 1: Cat. No. 1287 - EL4 Cell Lysate
Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 91 kDa
Observed: 96 kDa
Validation: N/A
Isoform: N/A
Purification: MALT1 antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: MALT1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: MALT1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: MALT1 was initially identified as a novel gene that was recurrently rearranged in t (11;18) (q21;q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1) . MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2, 3) . MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4) .
