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Product Description
TFEB Antibody | 6803 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: Rabbit polyclonal TFEB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TFEB.
The immunogen is located within amino acids 390 - 440 of TFEB.
Research Area: Autophagy
Tested Application: E, IHC-P, IF
Application: TFEB antibody can be used for detection of TFEB by immunohistochemistry at 2.5 μg/ml.
Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: TFEB antibody is human specific. At least three isoforms of TFEB are known to exist.
Positive Control 1: Cat. No. 10-101 - Human Lung Tissue Slide
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: TFEB antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: TFEB antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: TFEB antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: TFEB Antibody: TCFEB, BHLHE35, ALPHATFEB, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1, 2) . Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3) , which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4) . Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5) .
