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Product Description
TIRP Antibody | 3206 | ProSci
Host: Rabbit
Reactivity: Human
Homology: Predicted species reactivity based on immunogen sequence: Bovine: (77%)
Immunogen: TIRP antibody was raised against a peptide corresponding to 16 amino acids at the C-terminus of human TIRP.
The immunogen is located within the last 50 amino acids of TIRP.
Research Area: Innate Immunity
Tested Application: E, WB, ICC, IF
Application: TIRP antibody can be used for detection of TIRP by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: N/A
Positive Control 1: Cat. No. 1216 - PC-3 Cell Lysate
Positive Control 2: Cat. No. 17-007 - Raji Cell Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 26 kDa
Observed: 27 kDa
Validation: N/A
Isoform: N/A
Purification: TIRP Antibody is Ion exchange chromatography purified.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: TIRP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: TIRP antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: TIRP Antibody: TIRP, TRAM, TIRAP3, MyD88-4, TICAM-2, TIRP, TIR domain-containing adapter molecule 2, Putative NF-kappa-B-activating protein 502
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) . TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF) -6, and ultimately the activation of NF-κB. Expression of TIRP appears to be essential for TLR4 signalling.
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