Product Description
MRE11A Antibody | 18-710 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-205 of human MRE11A (NP_005581.2) .
Research Area: Cell Cycle, Immunology
Tested Application: WB, IF, IP
Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:200
IP: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: Raji
Positive Control 2: SW480
Positive Control 3: U-937
Positive Control 4: A-549
Positive Control 5: A-375
Positive Control 6: Mouse liver
Molecular Weight: Observed: 90kDa-100kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: MRE11 Antibody: ATLD, HNGS1, MRE11, MRE11B, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.