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![LAMP3 Antibody [LAMP3/529]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/575347/811934/porsci_lo__79508.1648973713__30324.1649091898.png?c=2 "LAMP3 Antibody [LAMP3/529]")
![LAMP3 Antibody [LAMP3/529]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/575347/811934/porsci_lo__79508.1648973713__30324.1649091898.png?c=2 "LAMP3 Antibody [LAMP3/529]")
Product Description
LAMP3 Antibody [LAMP3/529] | 33-510 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: Recombinant human protein was used as the immunogen for the LAMP3 antibody.
Research Area: Cancer, Immunology
Tested Application: WB, Flow, IF
Application: Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
Immunofluorescence: 0.5-1 ug/ml
Optimal dilution of the LAMP3 antibody should be determined by the researcher.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein G affinity chromatography
Clonality: Monoclonal
Clone: LAMP3/529
Isotype: IgG2a, kappa
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
Alternate Name: CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, LAMP-3, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, Tspan-30, CD63, CD63, MLA1, TSPAN30
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: This mAb recognizes protein of 26kDa-60kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
![LAMP3 Antibody [LAMP3/529]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/575347/811934/porsci_lo__79508.1648973713__30324.1649091898.png?c=2 "LAMP3 Antibody [LAMP3/529]")
