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![MSH2 Antibody [3A2B8C]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/553063/760793/porsci_lo__79508.1648973713__28362.1649086128.png?c=2 "MSH2 Antibody [3A2B8C]")
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Product Description
MSH2 Antibody [3A2B8C] | 32-196 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3) .
Research Area: Other
Tested Application: E, WB, IHC
Application: Western Blot:Dilution 1:200 - 1:1, 000
IHC (P) :Dilution 1:200 - 1:1, 000
IHC (F) :Dilution 1:200 - 1:1, 000
ELISA:Propose dilution 1:10, 000.
Determining optimal working dilutions by titration test.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: 3A2B8C
Isotype: IgG1
Conjugate: Unconjugated
Physical State: N/A
Buffer: Ascitic fluid containing 0.03% sodium azide.
Concentration: N/A
Storage Condition: MSH2 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: MutS protein homolog 2, hMSH2, FCC1, COCA1, HNPCC, LCFS2, HNPCC1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC) . The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI) . These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
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