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![TIGIT Antibody [10B1] (biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/552501/759757/porsci_lo__79508.1648973713__14447.1649084882.png?c=2 "TIGIT Antibody [10B1] (biotin)")
![TIGIT Antibody [10B1] (biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/552501/759757/porsci_lo__79508.1648973713__14447.1649084882.png?c=2 "TIGIT Antibody [10B1] (biotin)")
Product Description
TIGIT Antibody [10B1] (biotin) | RF16058-biotin | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT
Research Area: Immunology
Tested Application: E
Application: TIGIT antibody can be used for as detection antibody in Sandwich Elisa at 1 μg/mL.
Specificiy: N/A
Positive Control 1: Cat. No. 1340 - Human Stomach Carcinoma Tissue Lysate
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: TIGIT Antibody is supplied as protein A purified IgG1.
Clonality: Monoclonal
Clone: 10B1
Isotype: IgG1
Conjugate: biotin
Physical State: Liquid
Buffer: TIGIT Antibody is supplied in PBS containing 1% BSA and 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: TIGIT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: TIGIT Antibody: T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH) . TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1) . Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2) .
![TIGIT Antibody [10B1] (biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/552501/759757/porsci_lo__79508.1648973713__14447.1649084882.png?c=2 "TIGIT Antibody [10B1] (biotin)")
![TIGIT Antibody [10B1]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/552500/759755/porsci_lo__79508.1648973713__46647.1649084882.png?c=2 "TIGIT Antibody [10B1]")
