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Product Description
CD107a Antibody [H4A3] | 99-598 | ProSci
Host: Mouse
Reactivity: Human, Rhesus, African Green Monkey, Pigtail Macaque, Sooty Mangabey
Homology: N/A
Immunogen: Human adherent peripheral blood cells
Research Area: Innate Immunity
Tested Application: Flow
Application: CD107a Antibody [H4A3] for use in flow cytometry, immunohistochemistry / immunocytochemistry, electron microscopy, western blotting, immunoprecipitation, and purification assays.
Specificiy: CD107a
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [H4A3]
Isotype: IgG1
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: LAMP-1, lysosome-associated membrane protein 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1) , is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.
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