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Product Description
CD44 Antibody [F10-44-2] (APC) | 99-378 | ProSci
Host: Mouse
Reactivity: Human, Ma's Night Monkey
Homology: N/A
Immunogen: Purified human T cells
Research Area: Signal Transduction, Signal Transduction
Tested Application: Flow
Application: CD44 Antibody [F10-44-2] for use in flow cytometry assays.
Specificiy: CD44
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [F10-44-2]
Isotype: IgG2a
Conjugate: APC
Physical State: Liquid
Buffer: Supplied in PBS/NaN3 and a stabilizing agent
Concentration: Lot specific
Storage Condition: Store vial at 2-8˚C
Alternate Name: Pgp-1, H-CAM, ECMR-III, HUTCH-1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD44, also known as phagocytic glycoprotein-1 (Pgp-1) , exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing, and adhesion during hematopoiesis and lymphocyte activation.
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