Product Description
Cytokeratin 19 Antibody [SB39g] (FITC) | 99-633 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: Recombinant C-terminal cytokeratin 19
Research Area: Signal Transduction
Tested Application: IHC-Fr, Flow, IP, Separation
Application: Cytokeratin 19 Antibody [SB39g] for use in flow cytometry, immunocytochemistry, and western blotting assays.
Specificiy: Cytokeratin 19
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [SB39g]
Isotype: IgG2a
Conjugate: FITC
Physical State: Liquid
Buffer: Supplied in PBS/NaN3
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: CK 19, keratin 19
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8) . The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.