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![GSK-3a Antibody [SBGSK3a4] (Agarose)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/577259/815368/porsci_lo__79508.1648973713__00940.1649092348.png?c=2 "GSK-3a Antibody [SBGSK3a4] (Agarose)")
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Product Description
GSK-3a Antibody [SBGSK3a4] (Agarose) | 99-745 | ProSci
Host: Mouse
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: N/A
Research Area: Cell Cycle, Neuroscience, Signal Transduction
Tested Application: Flow
Application: GSK-3a Antibody [SBGSK3a4] for use in immunoprecipitation assays.
Specificiy: GSK-3alpha
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [SBGSK3a4]
Isotype: IgG2a
Conjugate: Agarose
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: Lot specific
Storage Condition: Store vial at 2-8˚C
Alternate Name: Glycogen synthase kinase-3
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3alpha and GSK-3beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
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