Product Description
hCG Receptor / LH Receptor Antibody [LHCGR/1416] | 33-715 | ProSci
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: A partial recombinant protein from the N-terminal region of human Luteinizing hormone / Choriogonadotropin receptor was used as the immunogen for the hCG Receptor antibody.
Research Area: Cancer
Tested Application: Flow, IF, WB
Application: Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
IF: 1-2 ug/ml
WB: 0.5-1 ug/ml
Optimal dilution of the hCG Receptor antibody should be determined by the researcher.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein G affinity chromatography
Clonality: Monoclonal
Clone: LHCGR/1416
Isotype: IgG1, kappa
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.2 mg/mL
Storage Condition: Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.
Alternate Name: LHCGR, luteinizing hormone/choriogonadotropin receptor, LCGR, LGR2, LHR, hLHR, luteinizing hormone receptor, lutropin/choriogonadotropin receptor, LH receptor, CG receptor, LHRHR
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: Recognizes a protein of 78-85kDa, which is identified as the receptor for Luteinizing hormone / Choriogonadotropin. Luteinizing hormone plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Choriogonadotropin production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone / choriogonadotropin receptor (LHCGR) as a seven transmembrane, G protein-coupled receptor glycoprotein. LHCGR influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of LHCGR on breast carcinoma correlates in part to the degree of tumor differentiation. LHCGR -positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women.