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![KSHVORF45 Antibody [2D4A5]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/553092/760867/porsci_lo__79508.1648973713__03247.1649086142.png?c=2 "KSHVORF45 Antibody [2D4A5]")
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Product Description
KSHVORF45 Antibody [2D4A5] | 32-228 | ProSci
Host: Mouse
Reactivity: Virus
Homology: N/A
Immunogen: Ni-NTA purified recombinant human KSHV ORF45 expressed in E. Coli strain BL21 (DE3) .
Research Area: Infectious Disease
Tested Application: E, WB
Application: Western Blot:1:500 - 1, 000
ELISA:Determining optimal working dilutions by titration test.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: 2D4A5
Isotype: IgG1
Conjugate: Unconjugated
Physical State: N/A
Buffer: Ascitic fluid containing 0.03% sodium azide.
Concentration: N/A
Storage Condition: to KSHV ORF45 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: Protein ORF45
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma- (2) -herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions.
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