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Product Description
HNMT Antibody | 18-684 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human HNMT (NP_008826.1) .
Research Area: Neuroscience
Tested Application: WB, IF, IP
Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:100
IP: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: 22RV1
Positive Control 2: NCI-H460
Positive Control 3: HT-29
Positive Control 4: HepG2
Positive Control 5: HeLa
Positive Control 6: Mouse liver
Molecular Weight: Observed: 33kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: Histamine N-methyltransferase, HMT, HNMT
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: In mammals, histamine is metabolized by two major pathways: N (tau) -methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N (tau) -methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
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