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Product Description
PYK2 (phospho Tyr579) Antibody | 79-886 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: PYK2 (phospho Tyr579) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 579 (E-D-Y (p) -Y-K) derived from Human PYK2.
Research Area: Phospho-Specific
Tested Application: WB, IHC
Application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificiy: The antibody detects endogenous levels of PYK2 only when phosphorylated at tyrosine 579.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 116 kDa
Validation: N/A
Isoform: N/A
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Condition: Store antibody at -20˚C for up to one year.
Alternate Name: CADTK, FADK 2, FAK2, PTK2B, RAFTK
User Note: N/A
BACKGROUND: Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.
