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Product Description
POLRMT (CT) Antibody | 9561 | ProSci
Product Type: Primary Antibodies
Research Area: Signal Transduction
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat
Homology: Predicted species reactivity based on immunogen sequence: Cow (82%) ; Chimpanzee (100%) ; monkey (82%) ; Cat (90%)
Immunogen: Anti-POLRMT antibody (9561) was raised against a peptide corresponding to 11 amino acids near the carboxyl terminus of human POLRMT.
The immunogen is located within the last 50 amino acids of POLRMT.
Tested Application: E, WB, IF
Predicted MW: Predicted: 139kD
Observed: 139 kD
Purification: POLRMT Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: POLRMT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage: POLRMT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Names: DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms
Background: POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.
Shipping Condition: Blue Ice
Source: N/A
Species: N/A
Peptide Location: N/A
By Source: N/A
By Species: N/A
Recombinant Protein Sequence: N/A
Badges: Trial Size, New
