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Product Description
RAD50 Antibody | 13-069 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: A synthetic peptide of human RAD50
Research Area: Cell Cycle
Tested Application: WB, IHC, IF
Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
IF: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: NIH3T3
Positive Control 2: MCF-7
Positive Control 3: A-549
Positive Control 4: HT-29
Positive Control 5: Mouse lung
Positive Control 6: N/A
Molecular Weight: Observed: 180kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: DNA repair protein RAD50, hRAD50, NBSLD, RAD502, hRad50
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
