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Product Description
GFM2 Antibody | 13-471 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 520-779 of human GFM2 (NP_115756.2) .
Research Area: Other
Tested Application: WB
Application: WB: 1:1000 - 1:4000
Specificiy: N/A
Positive Control 1: SW480
Positive Control 2: U-87MG
Positive Control 3: LO2
Positive Control 4: A-431
Positive Control 5: HT-1080
Positive Control 6: K-562
Molecular Weight: Observed: 86kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: EF-G2mt, EFG2, MRRF2, MST027, MSTP027, RRF, RRF2, RRF2mt, hEFG2, mEF-G 2, ribosome-releasing factor 2, mitochondrial, mitochondrial elongation factor G2, mitochondrial ribosome recycling factor 2
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
