Product Description
UGT1A6 Antibody | 13-387 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2) .
Research Area: Cancer, Signal Transduction
Tested Application: WB, IHC
Application: WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: HeLa
Positive Control 2: HepG2
Positive Control 3: SW480
Positive Control 4: MCF7
Positive Control 5: Mouse kidney
Positive Control 6: N/A
Molecular Weight: Observed: 75kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT-1A, UGT-1C, UGT-1E, UGT1, UGT1-01, UGT1-03, UGT1-05, UGT1.1, UGT1.3, UGT1.5, UGT1A, UGT1A1, UGT1A3, UGT1A5S, UGT1C, UGT1E, UGT1F, hUG-BR1, UGT1A6, UDP-glucuronosyltransferase 1-6, Bilirubin-specific UDPGT isozyme 1, UDP glucuronosyltransferase 1 family, polypeptide A6, UDP glycosyltransferase 1 family, polypeptide A6, UDP-glucuronosyltransferase 1 family polypeptide A6s, UDP-glucuronosyltransferase 1-1, UDP-glucuronosyltransferase 1-3, UDP-glucuronosyltransferase 1-5, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1-C, UDP-glucuronosyltransferase 1-E, UDP-glucuronosyltransferase 1-F, UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A3, UDP-glucuronosyltransferase 1A5, UDP-glucuronosyltransferase 1A6, UDPGT 1-1, UDPGT 1-3, UDPGT 1-5, UGT-1F, UGT1*6, UGT1-06, UGT1.6, phenol-metabolizing UDP-glucuronosyltransferase
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.