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![CD11b Antibody [M1/70] (APC)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/555350/764258/porsci_lo__79508.1648973713__66005.1649086618.png?c=2 "CD11b Antibody [M1/70] (APC)")
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Product Description
CD11b Antibody [M1/70] (APC) | 76-134 | ProSci
Host: Rat
Reactivity: Human, Mouse
Homology: N/A
Immunogen: N/A
Research Area: Innate Immunity
Tested Application: Flow
Application: N/A
Specificiy: The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) .
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality: Monoclonal
Clone: M1/70
Isotype: Rat IgG2b, kappa
Conjugate: APC
Physical State: liquid
Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration: batch dependent
Storage Condition: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
Alternate Name: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) . Mac-1 binds to C3bi, CD54 (ICAM-1) , and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
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