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![CD38 Antibody [NIMR-5]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576530/814365/porsci_lo__79508.1648973713__76804.1649092216.png?c=2 "CD38 Antibody [NIMR-5]")
![CD38 Antibody [NIMR-5]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/576530/814365/porsci_lo__79508.1648973713__76804.1649092216.png?c=2 "CD38 Antibody [NIMR-5]")
Product Description
CD38 Antibody [NIMR-5] | 98-748 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: BCL1 plasma membrane glycoproteins
Research Area: Cancer, Immunology, Obesity, Signal Transduction
Tested Application: IHC-P, IHC-Fr, Flow
Application: CD38 Antibody [NIMR-5] for use in flow cytometry, immunohistochemistry, immunoprecipitation, activation, stimulation, and blocking assays.
Specificiy: CD38
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [NIMR-5]
Isotype: IgG2a
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: T10, ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR) . It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.
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