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![CD40 Antibody [1C10]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576538/814376/porsci_lo__79508.1648973713__54026.1649092218.png?c=2 "CD40 Antibody [1C10]")
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Product Description
CD40 Antibody [1C10] | 98-762 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: sCD40
Research Area: Cancer, Immunology, Innate Immunity
Tested Application: WB, IHC-Fr, ICC, Flow
Application: CD40 Antibody [1C10] for use in flow cytometry, immunoprecipitation, activation, and blocking assays.
Specificiy: CD40
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [1C10]
Isotype: IgG2a
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: TNFRSF5, Bp50
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.
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