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![CD44 Antibody [IM7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/555624/764584/porsci_lo__79508.1648973713__41969.1649086658.png?c=2 "CD44 Antibody [IM7]")
![CD44 Antibody [IM7]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/555624/764584/porsci_lo__79508.1648973713__41969.1649086658.png?c=2 "CD44 Antibody [IM7]")
Product Description
CD44 Antibody [IM7] | 76-411 | ProSci
Host: Rat
Reactivity: Human, Mouse
Homology: N/A
Immunogen: N/A
Research Area: Functional Assays
Tested Application: Flow, Func
Application: N/A
Specificiy: The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) .
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality: Monoclonal
Clone: IM7
Isotype: Rat IgG2b, kappa
Conjugate: Unconjugated
Physical State: liquid
Buffer: Phosphate-buffered aqueous solution, ph7.2.
Concentration: batch dependent
Storage Condition: The product should be stored undiluted at 4˚C . Do not freeze.
Alternate Name: IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109, CD44
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24) . CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
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