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![CD44 Antibody [KM201] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/576424/814212/porsci_lo__79508.1648973713__62887.1649092196.png?c=2 "CD44 Antibody [KM201] (Biotin)")
![CD44 Antibody [KM201] (Biotin)](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/576424/814212/porsci_lo__79508.1648973713__62887.1649092196.png?c=2 "CD44 Antibody [KM201] (Biotin)")
Product Description
CD44 Antibody [KM201] (Biotin) | 98-539 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: (C57BL/6 x DBA/2) F1 mouse bone marrow-derived stromal clone BMS2
Research Area: Cancer, Immunology
Tested Application: E, IHC-P, IHC-Fr, ICC
Application: CD44 Antibody [KM201] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and immunoprecipitation assays.
Specificiy: CD44
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [KM201]
Isotype: IgG1
Conjugate: Biotin
Physical State: Liquid
Buffer: Supplied in PBS/NaN3
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Pgp-1, H-CAM, HUTCH-1, ECMR-III
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.
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