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![CD70 Antibody [FR70]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/555252/764148/porsci_lo__79508.1648973713__87394.1649086604.png?c=2 "CD70 Antibody [FR70]")
![CD70 Antibody [FR70]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/555252/764148/porsci_lo__79508.1648973713__87394.1649086604.png?c=2 "CD70 Antibody [FR70]")
Product Description
CD70 Antibody [FR70] | 76-031 | ProSci
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: N/A
Research Area: Immunology, Functional Assays
Tested Application: Flow, Func
Application: N/A
Specificiy: The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality: Monoclonal
Clone: FR70
Isotype: Rat IgG2b, kappa
Conjugate: Unconjugated
Physical State: liquid
Buffer: Phosphate-buffered aqueous solution, ph7.2.
Concentration: batch dependent
Storage Condition: The product should be stored undiluted at 4˚C . Do not freeze.
Alternate Name: Cd27l, CD27LG, Tnfsf7, Cd70
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
![CD70 Antibody [FR70]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/555252/764148/porsci_lo__79508.1648973713__87394.1649086604.png?c=2 "CD70 Antibody [FR70]")
![CD70 Antibody [FR70]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/555254/764150/porsci_lo__79508.1648973713__02663.1649086605.png?c=2 "CD70 Antibody [FR70]")
![CD70 Antibody [FR70]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/555253/764149/porsci_lo__79508.1648973713__17877.1649086605.png?c=2 "CD70 Antibody [FR70]")
